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Aconitum carmichaelii Debx
source:Chinese Herbal Plant Genome Database  time:2018-01-09 23:26:06

 

Year

2012

Institution

National TCM   Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese   Medicine and Key Laboratory of Chinese Materia Medica, Ministry of Education,   Heping Road 24, Harbin, 150040, China.

Material

Three main   forms of Yanfuzi (YFZ), Heishunpian (HSP) and Baifupian (BFP)

Results

Significant   changes of 19 metabolite biomarkers were detected in the Fuzi samples and   three preparations. The underlying regulations of Paozhi-perturbed metabolic   pathways were also discussed according to the identified metabolites.

Publication

Sun H, Ni B,   Zhang A, et al. Metabolomics study on Fuzi and its processed products using   ultra-performance liquid-chromatography/electrospray-ionization synapt   high-definition mass spectrometry coupled with pattern recognition   analysis[J]. Analyst, 2012, 137(1): 170-185.

 

Year

2017

Institution

Laboratory of   Ecology and Evolutionary Biology, State Key Laboratory for Conservation and   Utilization of BioResources in Yunnan University, Kunming, Peopleʼs Republic   of China

Material

A.   carmichaelii and seven other Aconitum species collected in   Yunnan Province.

Results

Using   orthogonal partial least squares discriminate analysis analysis, eight marker   compounds were identified, including 14-acetylkarakoline, aconitine,   carmichaeline, fuzi line,   hypaconitine, mesaconitine, neoline, and talatisamine. Four of these aconitum   alkaloids, fuziline, hypaconitine, mesaconitine, and neoline, showed   significant analgesic activity in a dose-dependent manner compared to the   negative and positive controls.

Publication

Zhao D, Shi Y,   Zhu X, et al. Identification of Potential Biomarkers from Aconitum   carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic Approach[J].   Planta medica, 2017.